NCOG-36. DOSIMETRY AND COGNITIVE FUNCTION AFTER RADIATION THERAPY IN LOW GRADE GLIOMAS

Abstract PURPOSE We found that cognitive function remained stable following radiotherapy with concurrent and adjuvant temozolomide (RT+TMZ) in low-grade glioma (LGG) patients evaluated prospectively up to 2 years. This study evaluates the effects of dosimetry on neurocognitive a larger group molecularly defined LGG treated (RT). METHODS A total 39 were comprehensive psychometric tests at baseline (prior RT) various time intervals RT. Patients served as their own controls by evaluating change scores over time. Dosimetric parameters included mean maximum dose pituitary, hypothalamus, contralateral hippocampus, brain, cochlea, PTV volume. Correlation between assessed Spearman correlation for Cox proportional hazard regression analysis survival analysis. RESULTS followed median 60 months. Overall, showed test similar initial performances all measures. There was significant cochlea (p=0.006), pituitary (p=0.035), volume (0.019) outcome.. CONCLUSION Cognitive prospectivelys. specific dosimetric endpoints outcomes Further needs be done population validate these findings.